Polyglutamine tracts regulate autophagy
نویسندگان
چکیده
منابع مشابه
Autophagy and polyglutamine diseases
In polyglutamine diseases, an abnormally elongated polyglutamine tract results in protein misfolding and accumulation of intracellular aggregates. The length of the polyglutamine expansion correlates with the tendency of the mutant protein to aggregate, as well as with neuronal toxicity and earlier disease onset. Although currently there is no effective cure to prevent or slow down the progress...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2017
ISSN: 1554-8627,1554-8635
DOI: 10.1080/15548627.2017.1336278